IgM ELISA Kit

IgM ELISA Kit 

Catalog Number: IGM-01-1157

Size: 1 plate (96 wells)

IgM ELISA Kit is a sandwich enzyme-linked immunoassay for the quantitative determination of IgM with high sensitivity and specificity in serum or plasma.

Kit Performance

• Sensitivity: 0.5 ng/mL
• Assay Range: 0.5 – 50 ng/mL
• Cross-reactivity: There is no cross reaction with native immunoglobulins
• Recovery rate: 80 – 120% with normal human serum or plasma samples with known concentrations.
• Precision

(CV (%) = SD/mean X 100)

• Intra-Assay: CV < 20%
• Inter-Assay: CV < 20%

Materials Supplied

List of component

Storage Instruction

The components arrive with ice pack, and must immediately be stored at 2-8°C. The kit components are stable at the date specified in CoA.

Supplementary information

Immunoglobulin M (IgM) is one of the five major classes of antibodies produced by B cells in the immune system. It is typically the first antibody generated during an initial immune response when the body encounters a new pathogen.

IgM is highly effective at activating the complement system, a group of proteins that enhance immune responses and help destroy pathogens.

In clinical and diagnostic settings, IgM is often used as an indicator of recent or acute infection. During many infections, IgM antibodies appear first, followed later by IgG antibodies as the immune response matures. Measuring IgM levels in blood can therefore help determine whether an infection is recent or ongoing. 

Several α-synuclein species are commonly measured as biomarkers in research and clinical studies, including total α-synuclein, oligomeric α-synuclein, and phosphorylated α-synuclein. Total α-synuclein reflects the overall protein level, while oligomeric α-synuclein represents aggregated soluble forms that are considered the most neurotoxic species and are believed to play a key role in neuronal damage. In addition, phosphorylated α-synuclein at serine 129 is strongly associated with pathological aggregation, as the majority of α-synuclein present in Lewy bodies is phosphorylated at this residue.

Measurement of these different α-synuclein species helps characterize disease pathology, progression, and therapeutic response in Parkinson’s disease studies.